Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy

Inclusion Criteria: * A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism, Platelet count \< 50\*10\^9/L * No evidence of PVT or spleno-mesenteric thrombosis by ultrasound evaluation and angio-CT * Informed consent to participate in the study Exclusion Criteria: * Hepatocellular carcinoma or any other malignancy * Hypercoagulable state other than the liver disease related * DRUGS- oral contraceptives, anticoagulation or anti-platelet drugs * Base line INR \>2 * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy * Uncontrolled Hypertension * Age\>75 yrs * F2 varices with red whale marks or F3 varices * Bleeding portal hypertension * Human immunodeficiency virus (HIV) infection