UnknownPhase 2

Effects of Folic Acid Supplementation on Arsenic Lowering

450 participantsStarted 2014-07

Plain-language summary

The purpose of this study is to determine whether folic acid supplementation are effective on arsenic lowering in a chronic, low-level arsenic exposed population.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men or women more than 18 years of age and chronically exposed to arsenic (arsenic concentration of the drinking water \>10ug/L); * Population who had no folic acid supplementation in the 2 weeks before the study; * Women of childbearing age agreed to use a reliable contraception method during the study; * Everyone volunteered to participate and signed informed consent. Exclusion Criteria: * Pregnant or breast-feeding women; * Allergic to folic acid; * Having clearly defined allergic history; * Reported long-term use of folic acid and other vitamins B; * Having obvious signs or laboratory abnormalities which could affect the efficacy of folic acid; * Unsuitable to participate in the study based on the judgment of the investigators; * Not agree to cancel the medications which may affect serum folate concentration during the study period; * Subjects who plan to become pregnant during the study or move out of the area within the study period;

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change of urine arsenic metabolites between baseline and week 8

Timeframe: baseline, week 8

Trial details

NCT IDNCT02235948

SponsorWenzhou Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

View on ClinicalTrials.gov More Arsenic Poisoning trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.