CompletedNot Applicable

Trigeminal Endonasal Perception: A Predictor for Septoplasty Outcome

Switzerland140 participantsStarted 2015-05

Plain-language summary

This study investigates wether patients with increased trigeminal perception threshold and low expression of TRP channels have more often nasal blockage despite functionally successful nasal surgery (TRP channel = transient receptor potential channel).

Who can participate

Age range18 Years – 99 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing a primary septoplasty and/or turbinoplasty * Patients suffering from empty nose syndrome after measurably successful nasal surgery * Patients with removed turbinates and/or septum, not suffering from ENS (i.e. tumor patients) Exclusion Criteria: * Patients with known neurologic disorders that could compromise perception threshold measurements * Patients with known allergies/intolerance to test agents that are used to measure perception thresholds (Cineol=Eucalypt; Menthol, CO2= Carbon Dioxide) * Inability to judge or understand the testing or the informed consent

What they're measuring

Measurement of subjective nasal breathing impairment after surgery depending on trigeminal perception threshold and TRP channel expression

Timeframe: Up to 1 year post-surgery

Trial details

NCT IDNCT02230423

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-04

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