CompletedNot Applicable

The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

Thailand51 participantsStarted 2014-10

Plain-language summary

Hypothesis 1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration. 2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
✓. Age 18 or older
✓. Can understand Thai (speaking, listening and reading)
✓. Agree to participate by written informed consent

Exclusion criteria

✕. Those who depend on others for feeding (such as stroke patients)
✕. Shift workers
✕. History of congestive heart failure or low ejection fraction
✕. Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT \> 3 times the upper limit of normal)
✕. Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
✕. Patients with permanent pacemaker
✕. History of previous stroke

What they're measuring

GLP-1 Levels in Response to Oral Glucose Tolerance Test

Timeframe: 2 weeks

Trial details

NCT IDNCT02229487

SponsorRamathibodi Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-03

Results submitted2017-05-01

View on ClinicalTrials.gov More Prediabetes trials