Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients (NCT02225886) | Clinical Trial Compass
UnknownPhase 4
Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients
Romania100 participantsStarted 2020-02-01
Plain-language summary
The administration of ascorbic acid seemed to increase the iron available for erythropoiesis, thus improving the anemia response to the treatment.
The investigators therefore aimed to evaluate the effects of intravenous ascorbic acid administration in hemodialysed patients with iron overload.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age above 18 years old
* At least 6 months on hemodialysis at the time of randomization;
* Kt/V≥1.2;
* average of the last three serum ferritin levels \> 500 ng/mL AND
* Average of the last three TSAT levels \> 20% and increasing
* ERI in the 4th quartile of the group
Exclusion Criteria:
* Active bleeding or other cause of anemia
* Serum level of intact parathyroid hormone (iPTH)\>800 pg/mL
* Actual neoplasia
* HIV, Hepatitis B or C infections
* Significant inflammation (CRP\>12mg/L) or acute infection
* Venous central catheter
* Severe hepatic, cardiovascular, psychic disease or other severe comorbidities
* Moderate or severe malnutrition
* Blood transfusions in the 2 months prior to screening
* Pregnancy or breastfeeding
* Inclusion in another clinical trial in the past month
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.