Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients

Inclusion Criteria: * Age above 18 years old * At least 6 months on hemodialysis at the time of randomization; * Kt/V≥1.2; * average of the last three serum ferritin levels \> 500 ng/mL AND * Average of the last three TSAT levels \> 20% and increasing * ERI in the 4th quartile of the group Exclusion Criteria: * Active bleeding or other cause of anemia * Serum level of intact parathyroid hormone (iPTH)\>800 pg/mL * Actual neoplasia * HIV, Hepatitis B or C infections * Significant inflammation (CRP\>12mg/L) or acute infection * Venous central catheter * Severe hepatic, cardiovascular, psychic disease or other severe comorbidities * Moderate or severe malnutrition * Blood transfusions in the 2 months prior to screening * Pregnancy or breastfeeding * Inclusion in another clinical trial in the past month