Efficacy and Safety Study of Tenofovir Disoproxil Fumarate (TDF) in Chinese Chronic Hepatitis B (CHB) Subjects With Advanced Fibrosis & Compensated Cirrhosis

Inclusion Criteria: * Age 18-60 years(inclusive); * Presence of HBsAg in serum at screening and for at least 6 months before screening assessment; * Serum HBV DNA\>=2000 IU/mL if HBeAg positive at screening (with or without ALT elevation); or serum HBV DNA\>=200IU/mL if HBeAg negative at screening (with or without ALT elevation); * Clinically diagnosed as advanced fibrosis or compensated cirrhosis defined as both of following : liver stiffness measure (LSM) \>12.4 kiloPascals (kpa) (ALT\> Upper limit of normal \[ULN\]) or LSM\>9.0 kpa (ALT\<=ULN); One of following: Liver biopsy showing advanced fibrosis or cirrhosis (Ishak score \>=4, within the previous 6 months before screening and provided that no treatment likely to improve liver histology has been taken since). The slides must be available for review by an independent histopathologist; Endoscopy-proven gastroesophageal or gastric varices, non-cirrhotic portal hypertension excluded; Abdominal ultrasound or CT found changes indicating cirrhosis, irregular liver surface or nodularity, with/without splenomegaly (depth of spleen\>4.0cm or spleen length\>13cm); Blood platelets \<100 x10\^9/L (and other causes of thrombocytopenia excluded); * Ability to give written informed consent; * A female is eligible to enter and participate in this study if she is of: non-childbearing potential (i.e., physiologically incapable of becoming pregnant, including any female who is post-menopausal), or Child-bearing potential, has a negative …