Mesenchymal Stem Cells Transplantation for Ischemic-type Biliary Lesions

Inclusion Criteria: * benign end-stage liver disease patients with liver transplantation. * ages of 18 and 60 years. * first liver transplant. * gamma-glutamyltransferase \> 300 U/L for 2 weeks, and there was no or low enhancement of the wall of the hilar bile duct in arterial phase via contrast-enhanced ultrasonography. * Written informed consent. Exclusion Criteria: * second or combined organ transplant recipient. * vital organs failure (Cardiac, Renal or Respiratory, et al). * clinically active bacterial, fungal, viral or parasitic infection. * other candidates who are judged to be not applicable to this study by investigators.