Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study

Inclusion Criteria: * Ability to give informed consent * Willing to participate in this study * Male or female ≥ 18 years of age at the time of the interview. * Subject has no diagnosed pulmonary condition * Subject has not smoked in the previous 5 years * Smoking history, if any, is less than or equal to 5 pack-years * Written informed consent (and assent when applicable) obtained from subject or subject's * legal representative and ability for subject to comply with the requirements of the study * Healthy subject that may or may not have undergone an fluorodeoxyglucose -Positron Emission Tomography (PET) scan Exclusion Criteria: * Any contraindication to MRI (presence of any non-removable metal implant, stents, pacemaker, clips, staples, or piercings, etc. ) * Subject does not fit in the magnet * Pregnancy or breast feeding * Severe claustrophobia * Subject is less than 18 years old * MRI is contraindicated based on responses to MRI screening questionnaire * Subject is pregnant or lactating * Respiratory illness of a bacterial or viral etiology within 15 days of MRI * Subject has received an investigational medicinal product (not including 129Xe) within 30 days of MRI * Subject has any form of known cardiovascular disease * Subject cannot hold their breath for 15 seconds * Subject deemed unlikely to be able to comply with instructions during imaging * Subject is taking beta blockers * Subject underwent an fluorodeoxyglucose-PET examination less than one week before the H…