CompletedNot Applicable

Pilot Study on Pairing Sedation Strategies and Weaning

United States90 participantsStarted 2014-12

Plain-language summary

A three-arm, randomized, pilot study, to assess the feasibility for the analgesia-first sedation (AFS) study arm/intervention (Fentanyl push first). The study will assess additional outcomes for all three (3) validated strategies for sedation and pain management.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. ≥ 18 years of age
✓. Mechanically ventilated with an expected duration of MV ≥ 48 hours
✓. ICU team has initiated continuous sedative and/or /analgesic infusions

Exclusion criteria

✕. Admission after resuscitation from cardiac arrest
✕. Admission with traumatic brain injury or another acute neurologic event (e,g. stroke, uncontrolled seizures).
✕. History of severe dementia
✕. Admission because of acute alcohol withdrawal or acute drug intoxication
✕. Administration of more than 24 hours of continuous sedation
✕. Allergy to fentanyl, midazolam, and/or propofol
✕. Lack of informed consent

What they're measuring

Study Feasibility

Timeframe: Up to 28 days

Trial details

NCT IDNCT02219659

SponsorMemorialCare Health System

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-05

Results submitted2020-08-19

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