Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers

Exclusion criteria

• ✕. An uninterpretable or abnormal screening electrocardiogram (ECG) indicating a second- or third-degree atrioventricular block, or one or more of the following: QRS interval \>110 milliseconds (msec); QT interval corrected by Fridericia's formula (QTcF) \>430 msec (males) and \>450 msec (females); PR interval \>200 msec; heart rate (HR) \<45 bpm; or any rhythm other than sinus rhythm that is interpreted by the investigator to be clinically significant.
• ✕. History of risk factors for torsades de pointes, including unexplained syncope, known long QT syndrome, heart failure, myocardial infarction, angina, or clinically significant abnormal laboratory assessments including hypokalemia, hypercalcemia, or hypomagnesemia. Subjects will also be excluded if there is a family history of long QT syndrome or Brugada syndrome.
• ✕. A sustained supine systolic blood pressure \>150 mm Hg or \<90 mm Hg or a supine diastolic blood pressure \>95 mm Hg or \<50 mm Hg at Screening or Check-in (Day -1). Blood pressure may be retested once in the supine position. The blood pressure abnormality is considered sustained if either the systolic or the diastolic pressure values are outside the stated limits after 2 assessments, and the subject may not be randomized.
• ✕. A resting HR of \<40 beats per minute or \>100 beats per minute when vital signs are measured at Screening or Check-in (Day -1).
• ✕. Unstable cardiovascular disease, including recent myocardial infarction or cardiac arrhythmia.
• ✕. Uncontrolled hypertension, asthma, unstable diabetes (type I or type II), thyroid disease, seizures, myasthenia gravis, or any other neuromuscular disorder.
• ✕. Women who are pregnant (or planning to become pregnant within the next 6 months) or currently breastfeeding.