Antioxidant Signature in Adult Patients With Phenylketonuria

Inclusion Criteria: * PKU patients over 18 years of age with phenylketonuria not treated with a phenylalanine-controlled diet. * Affiliation to a social security scheme * Reading and signing the informed consent * Control subjects: all healthy subjects over 18 years of unfulfilled abnormal metabolism of whatever nature and associated symptoms Exclusion Criteria: * Pregnancy of patients and control subjects women (confirmed by a negative pregnancy test) * Patients with diseases that may cause oxidative stress (neurodegenerative diseases, cancer) * Patients treated with drugs known to cause oxidative stress * Control subjects:controlled protein diet