The APPROACH Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia Syndrome

Inclusion Criteria: * History of chylomicronemia * A diagnosis of Familial Chylomicronemia Syndrome (Type 1 Hyperlipoproteinemia) * Fasting triglycerides (TG) ≥ 750 mg/dL (8.4 mmol/L) at Screening Exclusion Criteria: * Diabetes mellitus if newly diagnosed or if HbA1c ≥ 9.0% * Other types of severe hypertriglyceridemia * Active pancreatitis within 4 weeks of screening * Acute Coronary Syndrome within 6 months of screening * Major surgery within 3 months of screening * Treatment with Glybera therapy within 2 years of screening * Previous treatment with IONIS-APOCIIIRx * Have any other conditions in the opinion of the investigator which could interfere with the participant participating in or completing the study