Clip Placement Following Endoscopic Mucosal Resection - Randomised Trial

Inclusion Criteria: * Can give informed consent to trial participation * Lesion size greater than 20 mm * Lesion proximal to and inclusive of mid transverse colon * Laterally spreading or sessile polyp morphology Exclusion Criteria: * Previous resection or attempted resection of lesion * Clip deployed prior to the completion of the EMR * Major intraprocedural bleeding not treatable by coagulation * Endoscopic appearance of invasive malignancy * Age less than 18 years * Pregnancy * Active Inflammatory colonic conditions (e.g. inflammatory bowel disease) * Use of anticoagulant or antiplatelet agents other than aspirin less than 5 days prior to procedure * American Society of Anesthesiology (ASA) Grade IV-V