Active — Not RecruitingNot Applicable

Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure

United States2,050 participantsStarted 1996-06

Plain-language summary

The investigators are trying to learn more about the cause of kidney diseases such as Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic syndrome by studying genetics. The investigators are interested in discovering which genes play a role in causing a predisposition to FSGS/NS. The investigators also want to learn why FSGS/NS can run in families. Participation in our study involves a saliva sample and a urine sample that you can give from home. There is no cost to participate. All information is kept private and confidential. The investigators also like to include healthy volunteers (parents, spouses) if interested/available but of course this is completely optional.

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subjects with FSGS (focal segmental glomerulosclerosis) * Subjects with NS (nephrotic syndrome) * Subjects with unexplained kidney failure (have had a transplant or on dialysis) * Subjects with unexplained proteinuria * Family members of a person with FSGS, NS, kidney failure, or unexplained protein in their urine * Healthy volunteers Exclusion Criteria: * Patients whose kidney disease is already explained by another syndrome such as (Branchio Oto Renal Syndrome or Alports syndrome) * Patients who already know the genetic cause of their kidney disease

What they're measuring

To identify the genetic causes of FSGS, NS, and idiopathic proteinuria/ESRD in patients and families

Timeframe: 2035

Trial details

NCT IDNCT02194582

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2035-01

View on ClinicalTrials.gov More Focal Segmental Glomerulosclerosis trials