CompletedNot Applicable

Endogenous Opioid Mechanisms for Rejection Sensitivity

United States114 participantsStarted 2016-08

Plain-language summary

This project hypothesizes that the brain's opioid system determines rejection sensitivity, a personality trait that is a vulnerability factor and feature of several psychiatric disorders. This project will use positron emission tomography to measure the brain's opioid response to social rejection and acceptance in a nonclinical population with varying levels of rejection sensitivity. The results will provide the first major step towards understanding a neurotransmitter mechanism for rejection sensitivity, allowing for further investigation into predicting and treating its associated disorders.

Who can participate

Age range

18 Years – 25 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men and women age 18-25 (inclusive) * Right-handed * Native English speaker * Not currently in a romantic relationship * Willing and able to participate in a PET scan Exclusion Criteria: * Not on hormonal birth control * Not pregnant * Consume less than 5 cigarettes per week and less than 14 alcoholic drinks per week, on average * No use of recreational or street drugs in the past two years (e.g. marijuana) * Willing to abstain from alcohol and/or tobacco for 48 hours * No major untreated medical problems * Never diagnosed with a psychiatric or neurological disorder * Potential problems with having an MRI scan (claustrophobia, metal objects, etc.)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Mu-opioid binding potential

Timeframe: within 30 days of informed consent

Trial details

NCT IDNCT02189785

SponsorStony Brook University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-06-06

View on ClinicalTrials.gov More Rejection Sensitivity trials