CompletedNot Applicable

Endogenous Opioid Mechanisms for Rejection Sensitivity

United States114 participantsStarted 2016-08

Plain-language summary

This project hypothesizes that the brain's opioid system determines rejection sensitivity, a personality trait that is a vulnerability factor and feature of several psychiatric disorders. This project will use positron emission tomography to measure the brain's opioid response to social rejection and acceptance in a nonclinical population with varying levels of rejection sensitivity. The results will provide the first major step towards understanding a neurotransmitter mechanism for rejection sensitivity, allowing for further investigation into predicting and treating its associated disorders.

Who can participate

Age range18 Years – 25 Years

SexALL

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Inclusion Criteria: * Men and women age 18-25 (inclusive) * Right-handed * Native English speaker * Not currently in a romantic relationship * Willing and able to participate in a PET scan Exclusion Criteria: * Not on hormonal birth control * Not pregnant * Consume less than 5 cigarettes per week and less than 14 alcoholic drinks per week, on average * No use of recreational or street drugs in the past two years (e.g. marijuana) * Willing to abstain from alcohol and/or tobacco for 48 hours * No major untreated medical problems * Never diagnosed with a psychiatric or neurological disorder * Potential problems with having an MRI scan (claustrophobia, metal objects, etc.)

What they're measuring

Mu-opioid binding potential

Timeframe: within 30 days of informed consent

Trial details

NCT IDNCT02189785

SponsorStony Brook University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-06-06

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