CompletedNot Applicable

Radiotherapy of Motor Deficits From Metastatic Epidural Spinal Cord Compression

United States, Germany203 participantsStarted 2010-07

Plain-language summary

The primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 Gy and 10 x 3 Gy with respect to the effect on motor function in patients with metastatic epidural spinal cord compression.

Who can participate

Age range18 Years – 89 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Motor deficits of the lower extremities resulting from metastatic epidural spinal cord compression, which have persisted for no longer than 30 days * Confirmation of diagnosis by magnetic resonance imaging (spinal computed tomography allowed) * Relatively poor survival prognosis (defined as ≤35 points on the survival score published in Cancer 2008) * Written informed consent Exclusion Criteria: * Prior radiotherapy or surgery of the spinal areas affected by MESCC * History of symptomatic brain tumor or symptomatic brain metastases * Metastases of the cervical spine only * Other severe neurological disorders * Pregnancy, Lactation * Indication for decompressive surgery + stabilization of the affected spinal areas

What they're measuring

Number of Participants Showing Improvement or no Further Progression of Motor Deficits at 1 Month Following Radiotherapy

Timeframe: at 1 month following radiotherapy

Trial details

NCT IDNCT02189473

SponsorProf. Dirk Rades, MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

Results submitted2019-03-18

View on ClinicalTrials.gov More Metastatic Epidural Spinal Cord Compression trials