CompletedNot Applicable

Radiotherapy of Motor Deficits From Metastatic Epidural Spinal Cord Compression

United States, Germany, Lithuania203 participantsStarted 2010-07

Plain-language summary

The primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 Gy and 10 x 3 Gy with respect to the effect on motor function in patients with metastatic epidural spinal cord compression.

Who can participate

Age range

18 Years – 89 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Motor deficits of the lower extremities resulting from metastatic epidural spinal cord compression, which have persisted for no longer than 30 days * Confirmation of diagnosis by magnetic resonance imaging (spinal computed tomography allowed) * Relatively poor survival prognosis (defined as ≤35 points on the survival score published in Cancer 2008) * Written informed consent Exclusion Criteria: * Prior radiotherapy or surgery of the spinal areas affected by MESCC * History of symptomatic brain tumor or symptomatic brain metastases * Metastases of the cervical spine only * Other severe neurological disorders * Pregnancy, Lactation * Indication for decompressive surgery + stabilization of the affected spinal areas

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Number of Participants Showing Improvement or no Further Progression of Motor Deficits at 1 Month Following Radiotherapy

Timeframe: at 1 month following radiotherapy

Trial details

NCT IDNCT02189473

SponsorProf. Dirk Rades, MD

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

Results submitted2019-03-18

View on ClinicalTrials.gov More Metastatic Epidural Spinal Cord Compression trials

Who can participate

Age range

18 Years – 89 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.