Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications

Inclusion Criteria: * Older than 18 years-old, intubated and mechanically ventilated after out-of-hospital resuscitated cardiac arrest secondary to shockable rhythm * Hospitalized in an ICU * Mild therapeutic hypothermia procedure (32° to 35°C) scheduled (24 to 36 hours) * Delay from ROSC to randomisation \< 6 hours * Consent from family members or emergency consent Exclusion Criteria: * Pregnancy * Out-of-hospital cardiac arrest secondary to non shockable rhythm and In-hospital cardiac arrest * Need for cardiac support by cardiopulmonary bypass * Ongoing antibiotic therapy or during the week before * Ongoing or concomitant pneumonia * Known chronic colonization with MRB * Hypersensitivity to the active substances, to any of the penicillins or to any of the excipients. * History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam). * History of jaundice/hepatic impairment due to amoxicillin/clavulanic acid, according to the latest version of the SmPC. * Previous lung disease * Predictable decision of early care limitation * Patient under guardianship or curatorship * Moribund patient * Participation to another trial within 30 days