CompletedNot Applicable

Biomarkers in Patients With Flesh-eating Bacterial Infections

Denmark169 participantsStarted 2013-02

Plain-language summary

The purpose of this study is to investigate the immune response in patients with necrotizing soft tissue infections (NSTI). The investigation will focus on inflammatory and vasoactive biomarkers as prognostic markers of severity and mortality at admission to Rigshospitalet and the following 3 days

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for patients with NSTI: * Necrotizing soft tissue infection based on surgical findings * Age \>18 years * Admitted to/planned to be admitted to the ICU at Rigshospitalet and/or operated for NSTI at Rigshospitalet Exclusion Criteria for patients with NSTI: * Patients who at the operating theatre were categorized as non-NSTI patients Inclusion Criteria for control patients: * Patients undergoing elective orthopedic surgery (non-pathologic fractures, joint replacement surgery, back surgery) at Rigshospitalet * Age \>18 years Exclusion Criteria for control patients: * Patients with ongoing infections

What they're measuring

PTX3, NOx and IL-6 as early markers of disease severity in NSTI patients with and without septic shock

Timeframe: Admission, first 24 hours

Trial details

NCT IDNCT02180906

SponsorOle Hyldegaard

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-02

View on ClinicalTrials.gov More Necrotizing Soft Tissue Infection trials