CompletedNot Applicable

Impact of the Lab-score on Antibiotic Prescription Rate in Children With Fever Without Source

Switzerland278 participantsStarted 2010-09

Plain-language summary

Detecting serious bacterial infections (SBI) in children presenting to the Pediatric Emergency Department (PED) with fever without source (FWS) is a frequent diagnostic challenge. The recently described Lab-score, based on the combined determination of Procalcitonin, C-Reactive Protein (CRP) and urine dipstick results, has been shown an accurate tool for SBI prediction on retrospective cohorts. The investigators aimed to assess the usefulness of the Lab-score in safely decreasing unnecessary antibiotic prescriptions in children with FWS, and to prospectively determine the diagnostic characteristics of the Lab-score compared to other classically used SBI biomarkers (white blood cell (WBC) count, band count and CRP).

Who can participate

Age range7 Days – 3 Years

SexALL

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Inclusion Criteria: * children aged 7 days to 3 years old * fever without source ≥ 100.4°F (≥ 38.0°C) Exclusion Criteria: * antibiotics received in the previous 48 hours * underlying congenital or acquired immunodeficiency syndrome * fever for more than 7 days at presentation

What they're measuring

Antibiotic Prescription Rate

Timeframe: at PED (Pediatric Emergency Department) presentation

Trial details

NCT IDNCT02179398

SponsorUniversity Hospital, Geneva

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-07

Results submitted2014-10-21

View on ClinicalTrials.gov More Fever Without Source trials