Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Inclusion Criteria: * Patient must have newly diagnosed, histologically confirmed GBM. * Patient must have undergone gross total resection, subtotal resection, or biopsy with the extent of resection determined by the treating neurosurgeon, and must begin radiation within 12 weeks of this procedure. * Patients must not have received previous irradiation to the brain. * Patient must be at least 18 years of age since the diagnosis of GBM in patients younger than 18 is rare and accurate evaluation of neurocognitive function would require a different battery of examinations than employed in this study. * ECOG performance status 0-2 (Karnofsky \>60%; see Appendix A). * Patient must be scheduled to receive temozolomide concurrent with and following radiation (temozolomide may be started late due to insurance reasons, insufficient counts, or other reasons). * If a woman is of child-bearing potential, a negative urine or serum pregnancy test must be demonstrated prior to treatment. Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation and for up to 12 weeks following the study. Should a women become pregnant or suspect she is pregnant while participating in this study she should inform her treating physician immediately. * Patient must have the ability to understand and the willingness to sign a written informed consent document. * All patients must be informed…