High-Dose Lymph Node Intensity Modulated Radiation Therapy and Hypofractionated Prostate (SIB)

Inclusion Criteria: * Histologically confirmed, adenocarcinoma of the prostate * T1-2N0M0 with risk of pelvic lymph nodes involvement \>25% by Roach formula \[(2/3xPSA) + (Gleason Score - 6)x10\], or any T3-4N0M0 * Karnofsky Performance Scale \> 70. * Prostate tumor biopsy grading by Gleason score classification is mandatory prior to registration. * No prior pelvic or prostate radiation or chemotherapy for any reason; induction hormonal therapy prior to registration is acceptable. * Patients must sign a study-specific consent form prior to registration. * No evidence of distant metastases (Bone scanning) Exclusion Criteria: * Clinical or pathological evidence of distant metastases (M1). * Radical surgery for carcinoma of the prostate * History of prior chemotherapy * History of prior pelvic radiation therapy * Children (age \< 18).