TerminatedNot Applicable

Chronotherapy Randomized Controlled Trial

Stopped: PI

United States13 participantsStarted 2014-06-01

Plain-language summary

Chronotherapy is a term that describes therapeutic alterations of sleep wake cycles. Different variations of sleep deprivation, set sleep wake schedules, and types of light therapy have demonstrated efficacy in rapidly treating depression, and suicidal thinking. This study seeks to explore the effect of two different chronotherapuetic protocols on acutely depressed and suicidal inpatients admitted to the Medical University of South Carolina

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A current episode of non-psychotic major depression * Currently hospitalized * Age greater than 18 * If bipolar illness, must not be a mixed state, and must be on a therapeutic dose of a mood stabilizer Exclusion Criteria: * Urine drug screen positive for cocaine, or current alcohol/dependence that requires detox * current psychosis * Panic Disorder * Severe Borderline Personality Disorder * A history of seizures, uncontrolled severe headaches, stroke, or other neurologic illness that produces either gait abnormalities or lowered seizure threshold * Medical illness that would make wake therapy intolerable * Cataracts, glaucoma, or other intrinsic eye condition * Currently taking light sensitizing medications * Current pregnancy * Mental retardation or dementia * Untreated sleep disorder such as Obstructive Sleep Apnea(OSA), narcolepsy, or periodic limb movement disorder(PLMD) that results in excessive sleepiness * Currently receiving electroconvulsive therapy (ECT)

What they're measuring

Hamilton Depression Rating Scale

Timeframe: Day prior to total sleep deprivation, and then again over the next 4 consecutive days. There will then be a continuation phase where data will be collected at one week, two weeks, 4 weeks, and 8 weeks.

Columbia Suicide Severity Rating Scale

Trial details

NCT IDNCT02176824

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-04-07

View on ClinicalTrials.gov More Major Depressive Disorder trials