WithdrawnPhase 4

Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery

Stopped: I retired my post before enrollment

Japan0Started 2014-07

Plain-language summary

* It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI). * Sevoflurane may increase the risk for postoperative AKI because of production of compound-A. * Therefore, we have planned to investigate the effects of different anesthetic agents on postoperative renal function. * Patients undergoing liver resection surgery are randomized into 2 groups. * One of the groups receives sevoflurane and the other group receives desflurane. * Blood and urine specimen are sampled both pre- and postoperatively, and several biomarkers are compared between the groups.

Who can participate

Age range20 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Forty adult patients (20 patients in each group) who are planned to undergo liver resection surgery are included. Exclusion Criteria: * Patients who undergo less invasive resection surgery under thoracoscopy or laparoscopy are excluded. Patients with chronic kidney disease, or allergic to any anesthetic agents used in the study are also excluded.

What they're measuring

Postoperative acute kidney injury

Timeframe: within 72 hours postoperatively

Trial details

NCT IDNCT02174575

SponsorTokyo Medical and Dental University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05

View on ClinicalTrials.gov More Hepatocellular Carcinoma trials