TerminatedNot Applicable

Remote Preconditioning Over Time To Empower Cerebral Tissue

Stopped: COVID 19 restrictions

United States6 participantsStarted 2015-11

Plain-language summary

Previous studies in animals and humans has shown that brief periods of reduced blood flow to one organ or tissue in the body can help protect other tissues from subsequent injury caused by reduced blood flow such as a stroke. This phenomenon is known as remote ischemic preconditioning and may help protect brain cells after a stroke. The investigators are studying a specific stroke type called subcortical stroke that is very common and has a high rate of recurrent stroke and cognition problems despite intensive prevention measures.

Who can participate

Age range40 Years

SexALL

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Inclusion criteria

✓. Clinical lacunar stroke syndrome within the past 6 months
✓. Absence of signs or symptoms of cortical dysfunction
✓. No proximal large vessel atherosclerosis, intracranial atherosclerosis or cerebellar stroke.
✓. No major cardioembolic source requiring anticoagulation or other specific therapy
✓. Magnetic Resonance Imaging (MRI) presence of a small subcortical ischemic, any 1 or more of:
✓. Diffusion-weighted imaging (DWI) lesion \< 2.0cm in size at largest dimension and corresponding to the clinical syndrome.
✓. Well delineated focal hyperintensity \<2.0 cm in size at largest dimension (including rostro-caudal extent) on FLAIR or T2 and clearly corresponding to the clinical syndrome. If other focal hyperintensities are present, the case will be discussed with the principal investigator prior to randomization
✓. Multiple (at least 2) hypointense lesions of size 0.3-1.5 cm at largest dimension (including rostro-caudal extent) only in the cerebral hemispheres on FLAIR or T1 in patients whose qualifying event is clinically hemispheric

Exclusion criteria

What they're measuring

Duration of Adherence to Ischemic Preconditioning Procedure

Timeframe: 12 months

Trial details

NCT IDNCT02169739

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-03

Results submitted2021-02-16

View on ClinicalTrials.gov More Ischemic Stroke trials