TerminatedNot Applicable

Remote Preconditioning Over Time To Empower Cerebral Tissue

Stopped: COVID 19 restrictions

United States6 participantsStarted 2015-11

Plain-language summary

Previous studies in animals and humans has shown that brief periods of reduced blood flow to one organ or tissue in the body can help protect other tissues from subsequent injury caused by reduced blood flow such as a stroke. This phenomenon is known as remote ischemic preconditioning and may help protect brain cells after a stroke. The investigators are studying a specific stroke type called subcortical stroke that is very common and has a high rate of recurrent stroke and cognition problems despite intensive prevention measures.

Who can participate

Age range

40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Clinical lacunar stroke syndrome within the past 6 months
. Absence of signs or symptoms of cortical dysfunction
. No proximal large vessel atherosclerosis, intracranial atherosclerosis or cerebellar stroke.
. No major cardioembolic source requiring anticoagulation or other specific therapy
. Magnetic Resonance Imaging (MRI) presence of a small subcortical ischemic, any 1 or more of:
. Diffusion-weighted imaging (DWI) lesion \< 2.0cm in size at largest dimension and corresponding to the clinical syndrome.
. Well delineated focal hyperintensity \<2.0 cm in size at largest dimension (including rostro-caudal extent) on FLAIR or T2 and clearly corresponding to the clinical syndrome. If other focal hyperintensities are present, the case will be discussed with the principal investigator prior to randomization

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Duration of Adherence to Ischemic Preconditioning Procedure

Timeframe: 12 months

Trial details

NCT IDNCT02169739

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-03

Results submitted2021-02-16

View on ClinicalTrials.gov More Ischemic Stroke trials

Plain-language summary

Who can participate

Age range

40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Clinical lacunar stroke syndrome within the past 6 months
. Absence of signs or symptoms of cortical dysfunction
. No proximal large vessel atherosclerosis, intracranial atherosclerosis or cerebellar stroke.
. No major cardioembolic source requiring anticoagulation or other specific therapy
. Magnetic Resonance Imaging (MRI) presence of a small subcortical ischemic, any 1 or more of:
. Diffusion-weighted imaging (DWI) lesion \< 2.0cm in size at largest dimension and corresponding to the clinical syndrome.
. Well delineated focal hyperintensity \<2.0 cm in size at largest dimension (including rostro-caudal extent) on FLAIR or T2 and clearly corresponding to the clinical syndrome. If other focal hyperintensities are present, the case will be discussed with the principal investigator prior to randomization

Remote Preconditioning Over Time To Empower Cerebral Tissue

Plain-language summary

Who can participate

Inclusion criteria

Questions worth asking your doctor

Questions for the trial coordinator

What they're measuring

Trial details

Remote Preconditioning Over Time To Empower Cerebral Tissue

Plain-language summary

Who can participate

Inclusion criteria

Questions worth asking your doctor

Questions for the trial coordinator

What they're measuring

Trial details

Exclusion criteria