Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum

Inclusion criteria

• ✓. Have received at least 2 administrations of intravenous (iv) hydration separated by at least 1 week or daily emesis for at least the last 14 days and 1 administration of iv hydration.
• ✓. Have at least one of the following: 2-4+ ketonuria, serum potassium \< 3.4mmol, or \>5% weight loss from weight upon entry to prenatal care.
• ✓. Have failed therapy with at least one antiemetic.
• ✓. Have fetal ultrasound within 6 weeks prior to enrollment confirming a normal-appearing, intrauterine, singleton pregnancy of gestational age \< 16 weeks at time of enrollment.
• ✓. Felt by the patient's obstetrician or emergency room attending physician not to have other medical problems such as bowel obstruction, pancreatitis, biliary colic, or peptic ulcer disease that could be contributing to the patient's symptoms.
• ✓. Be \>18 years old and not decided to terminate the pregnancy.
• ✓. Have not received or planning to receive a peripherally inserted central catheter (PIC line).
• ✓. Have a Motherisk-PUQE score of ≥12 for the 24-hour Baseline period.