CompletedNot Applicable

Immunopathology of Autoimmune Hemolytic Anemia

France27 participantsStarted 2013-07-03

Plain-language summary

Autoimmune hemolytic anemia (AIHA) is an auto-immune disease mediated by specific antibodies targeting red blood cells. Its pathogenesis is not completely understood, and the role of T cells have been rarely studied. The aim of this study is to compare the frequency of circulating T cells, T cell polarization and functions, notably regulatory T cells, during warm AIHA by comparison to healthy controls. The role of treatments, such as steroids, will also be determined in patients with warm AIHA.

Who can participate

Age range16 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients diagnosed with primary warm Autoimmune Hemolytic Anemia (wAIHA) * Secondary AHAI (infections, hematological diseases, systemic diseases) * Naive of treatment for hemolytic anemia or in relapse * Older than 16 * Able to understand written and spoken French * who have provided written informed consent * INCLUSION CRITERIA for CONTROLS * Persons without auto-immune disease, cancer or active infection. * Older than 16 * Able to understand written and spoken French * who have provided written informed consent Exclusion Criteria: * Cold agglutinin disease * Pregnancy * Persons without national health insurance Exclusion Criteria for Controls: * Subjects treated with corticosteroids or immunosuppressants * Pregnancy * Persons without national health insurance

What they're measuring

physiological parameter : blood level of regulatory T cells (Treg, CD4+CD25HighFoxp3+)

Timeframe: Change from baseline to 3 months

physiological parameter : percentage of inhibiting LT proliferation inhibition

Timeframe: Change from baseline to 3 months

Trial details

NCT IDNCT02158195

SponsorCentre Hospitalier Universitaire Dijon

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-12-27