Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome

Inclusion Criteria: * Men, women, and children of any age or ethnic group who meet eligibility * Patients under 18 years of age must be accompanied and co-consented, by a parent or legal guardian. * Patients must have a diagnosis of Basal Cell Nevus Syndrome (BCNS) * For diagnosis of BCNS, the patient must have either 2 major criteria, one major and two minor criteria, or one major criterion plus molecular confirmation of a PTCH1 gene mutation * Major criteria are: * (1) BCC prior to age 20 years, or excessive number of BCCs out of proportion to prior sun exposure and skin type * (2) keratocyst of the jaw prior to age 20 * (3) palmar or plantar pitting * (4) lamellar calcification of the falx cerebri * (5) medulloblastoma * (6) first degree relative with BCNS * Minor criteria are: * (1) rib anomalies, or other specific skeletal malformations including kyphoscoliosis and short 4th metacarpals * (2) macrocephaly * (3) cleft/lip or palate; * (4) fibroma of the heart or ovary * (5) ocular abnormalities * (6) other rare abnormalities * At least two BCC tumors, preferably more, located in different body regions or located greater than 10 cm apart in locations that can be reproducibly separated into red and blue illumination fields * Female subjects are not pregnant or nursing or planning to become pregnant during the study * Subjects must have the ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: *…