CompletedNot Applicable

Evaluation of the Effects of Eccentric Training on a Cycle Ergometer, Versus Conventional Concentric Training

France212 participantsStarted 2013-09-16

Plain-language summary

The aim of this study is to assess the efficacy of a rehabilitation protocol based on individualized combined eccentric and concentric cycle ergometer training compared to classical concentric cycle training among patients with either coronary artery disease (CAD) or chronic obstructive pulmonary disease (COPD). This study will therefore evaluate the efficacy of combined eccentric/concentric training on physical capacity and overall autonomy, and will analyse the adaptive mechanisms with regard to both adaptation to cardiac and muscular effort and tolerance.

Who can participate

Age range40 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Persons who have provided written informed consent Healthy volunteers: * Men or women aged between 40 and 75 years. Patients with CAD: * Men or women aged between 40 and 75 years, with coronary artery disease without heart failure referred for a rehabilitation program. * Left ventricular ejection fraction on echocardiography (Simpson methode) \> 45 % Patients with Chronic obstructive pulmonary disease: * Men or women aged between 40 and 75 years * Severe Chronic obstructive pulmonary disease (post-bronchodilatator FEV1/FVC \< 0.70 and FEV1 ≤ 60% of predicted value) * Patient not on oxygen therapy (24h/24) Exclusion Criteria: * Person without national health insurance cover * Severe, obstructive cardiopathy * Severe aortic valve stenosis, * Severe progressive heart rhythm or conduction disorders not corrected by a pacemaker and detected during the initial effort test * Cardiac intracavitary thrombus, * Severe pulmonary artery hypertension (PAHT systolic \>70mmHg), * Recent history of venous thromboembolism (previous 3 months), * Impaired executive functions making it impossible to understand and adhere to a rehabilitation program (Mini Mental Test \< 24), * Heart transplant, * Associated medical condition that could substantially affect functional capacities (examples: non-stabilized metabolic disorders such as progressive renal insufficiency, major asthenia linked to a severe non-stabilized disorder such as neoplasia, systemic disease…). * Physi…

What they're measuring

For patients with CAD: Distance covered during a 6-minute walk test and triceps surae maximal isometric force

Timeframe: Between the initial evaluation (D0) and the final reconditioning evaluation, assessed up to 8 weeks

For COPD patients : Endurance time at 75 % of peak workload achieved on a cycle ergometer during the initial concentric cardiopulmonary exercise test (CPET)

Timeframe: Between the initial evaluation (D0) and the final reconditioning evaluation, assessed up to 8 weeks

Trial details

NCT IDNCT02156245

SponsorCentre Hospitalier Universitaire Dijon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-04-03

View on ClinicalTrials.gov More Readaptation to Effort trials

Plain-language summary

Who can participate

Age range40 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

For patients with CAD: Distance covered during a 6-minute walk test and triceps surae maximal isometric force

Timeframe: Between the initial evaluation (D0) and the final reconditioning evaluation, assessed up to 8 weeks

For COPD patients : Endurance time at 75 % of peak workload achieved on a cycle ergometer during the initial concentric cardiopulmonary exercise test (CPET)

Timeframe: Between the initial evaluation (D0) and the final reconditioning evaluation, assessed up to 8 weeks