Comparison of Agent™ and SeQuent® Please Paclitaxel Coated Balloon Catheters in Coronary In-stent Restenosis (AGENT-ISR)

Inclusion Criteria: * Subject must be at least 18 years of age * Subject is willing and able to provide informed consent * Subject is eligible for percutaneous coronary intervention * Subject is willing to comply with all protocol-required follow-up evaluations * Women of child-bearing potential must agree to use a reliable method of contraception * In-stent restenosis in a lesion previously treated with either a drug-eluting or bare metal stent, located in a native coronary artery with a reference vessel diameter ≥ 2.0 mm and ≤ 3.5 mm * Target lesion length must be ≤ 28 mm (by visual estimate) and must be covered by only one balloon * Target lesion must have visually estimated stenosis ≥ 70% and \< 100% in asymptomatic patients * Target lesion must have visually estimated stenosis ≥ 50% and \< 100% in symptomatic patients * Thrombolysis in Myocardial Infarction (TIMI) grade flow in the target lesion must be ≥ 1 * Target lesion must be successfully pre-dilated. Exclusion Criteria: * Patient has life expectancy of less than 24 months * Patient with known coronary artery spasm * Patient with unprotected left main coronary artery disease * Patient has current problems with substance abuse * Patient has planned procedure that may cause non-compliance with the protocol or confound data interpretation * Patient is participating in another investigational drug or device clinical study that has not reached its primary endpoint * Patient intends to participate in another investigat…