AVAILABLENot Applicable

Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation

South KoreaStarted 2014-05

Plain-language summary

To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.

Who can participate

Age range16 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. patient with eye which has limbal stem cell deficiency and conjunctivalization of cornea
✓. patient who shows no improvement after limbal tissue or amniotic membrane transplantation, or who has difficulty in receiving long-term immunosuppressive treatment
✓. patient who agree this clinical trial
✓. patient with the eyes in which best corrected visual acuity is less than counting finger
✓. patient who is older than sixteen year old

Exclusion criteria

✕. patient who has relevant corneal transparency
✕. patient who is on the pregnancy or has a plan of pregnancy within 1 year
✕. patient who has corneal infection
✕. patient who has diagnosis of HBV, HCV, HIV, syphilis
✕. patinet who has past medial history of antinal, myocardial infarction, heart failure, arrhythmia, brain stroke, cerebrovascular disease
✕. patient who has malignancy
✕. patient who shows hypersensitivity to bovine protein.

Trial details

NCT IDNCT02149732

SponsorSeoul National University Hospital

Sponsor typeOTHER

Study typeEXPANDED_ACCESS

Primary completion2016-12

Contact for this trial

Mee Kum Kim, MD, PhD

82-10-6277-0798 kmk9@snu.ac.kr

View on ClinicalTrials.gov More Limbal Stem Cell Deficiency trials