TerminatedPhase 3

Gcsf Injection in Women With Repeated Implantaiton Failure

Stopped: Recruitment difficulty

Canada15 participantsStarted 2013-03

Plain-language summary

The purpose of the study is to see the impact of intrauterine injection of recombinant GCSF on pregnancy and implantation rate during IVF-ICSI (intracytoplasmic sperm injection) protocols as well as in frozen embryo transfer. In addition, following the injection, the level of G-CSF in the bloodstream will be verified.

Who can participate

Age range18 Years – 37 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women between the ages of 18 and 37 * Indication of the Antagonist IVF protocol or indication of a substituted frozen embryo transfer * Subjects with repetitive embryo implantation failure meaning: a history of 3 embryos transferred including frozen embryo without a positive pregnancy test for women 35 years and younger * Subjects with repetitive embryo implantation failure meaning: a history of 4 embryos transferred including frozen embryo without a positive pregnancy test for women between the ages of 35 and 37. * Negative repetitive implantation failure work up Exclusion Criteria: * Renal failure or cardiac failure * Chronic neutropenia * Past or present cancer history * Sickle cell anemia * Lithium treatment * Voluntary withdrawal from the study * Use of concomitant medication: DHEA (dehydroepiandrosterone ), CoQ10 (coenzyme Q10), Growth Hormone and Viagra

What they're measuring

Dosage of G-CSF

Timeframe: up to 3 years

Pregnancy and Implantation

Timeframe: up to 3 years

Trial details

NCT IDNCT02149277

SponsorClinique Ovo

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2017-12

View on ClinicalTrials.gov More Repeated Embryo Implantation Failure trials