Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

Inclusion Criteria: * Subject has been receiving in-center hemodialysis for ≥ 3 months and are currently on a schedule of 3 times a week. * Subject self-categorized themselves on the Patient Assessed Disease Severity Scale during Screening * Subject meets standard of care hemodialysis efficiency guidelines during the three months prior to completing Screening * Have demonstrated pruritus intensity on the Itch NRS during screening * Male or female who are at least 18 years old at the time of Screening Exclusion Criteria: * Subject had a significant alteration in dialysis regimen during the Screening Period * Subject receiving or anticipated to be receiving nocturnal dialysis or home hemodialysis treatment during the study. * Subject has pruritus that is believed to be caused by a condition unrelated to end-stage renal disease * Has had a history of substance abuse within 6 months prior to completing Screening * Subject has a known drug allergy to opioids * Subject is a pregnant or lactating female.