Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer

Inclusion Criteria: * Women with histologically confirmed cervical, vaginal or vulvar high-grade dysplasia, invasive squamous cell carcinoma, invasive adenocarcinoma, or adenocarcinoma-in-situ (AIS). All stages and grades will be eligible. * Women with a diagnosis of high grade intraepithelial lesion (HSIL) from a routine pap test. * Patients must sign an approved informed consent document. Exclusion Criteria: * Patients with previously documented perianal squamous cell dysplasia or invasive squamous cell carcinoma of the anus or anal canal. * Patients unwilling or unable to provide informed consent for the study. * Male patients will not be included in this study. * Patients with previously documented HPV related oropharyngeal cancer.