The aim of this pilot research project is to compare the clinical effect on dentinal hypersensitivity of three products: Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) paste with fluoride, 5000 Sodium Fluoride (NaF) dentifrice containing Tri-Calcium Phosphate (TCP), and a dentifrice containing Potassium Nitrate.
The hypothesis of this study is that CPP-ACP with fluoride and 5000ppm NaF with TCP will exhibit a greater reduction in dentinal hypersensitivity compared to the control (dentifrice containing Potassium Nitrate).
The results of this pilot study will validate or negate the need for a larger clinical study that may provide generalizable results for using caries-prevention products with the additional benefit of minimizing dentinal hypersensitivity.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* At least 18 years of age
* Tooth with exposed root surface and/or exposed dentin
* Tooth with a VAS score greater than or equal to 3
* No adjacent tooth/teeth with sensitivity (as defined as 2 or higher on the VAS)
Exclusion Criteria:
* Participation in another dental study that may alter the results of this study.
* A medical condition that could interfere with reliable pain reporting (e.g., pain disorders)
* Any chronic medical condition that requires the regular use of pain or anti-inflammatory medications
* Used a desensitizing dentifrice within the preceding four weeks
* Have received an antihypersensitivity treatment (varnish or precipitating solution) of the identified tooth within the preceding four weeks
* Undergoing active orthodontic treatment.
* Teeth with carious lesions, buccal vertical cracks in enamel, evidence of irreversible pulpitis (pain lasting more than five seconds after air stimulation)
* Pregnant/ lactating patients (Clinpro5000 has 5000ppm fluoride and there is a risk of ingesting the product)
* Patients with Milk Allergy (CPP-ACP is a dairy based product)
* Patients on Kidney Dialysis (due to the free calcium in CPP-ACP, dialysis patients should be on a diet with limited calcium)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at caries prevention products for dentinal hypersensitivity — can you explain whether any of those products have since become part of standard dental care, or if the results changed what you'd recommend for my sensitivity?
2Since this trial is listed as 'Phase NA,' which often means it involved marketed or consumer-type products rather than experimental drugs, does that change how confident you are in the safety profile compared to a typical drug trial?
3The trial has already been completed — is there published data from it that you've reviewed, and does anything in those findings apply to my specific type of tooth sensitivity?
4Are there standard treatments for dentinal hypersensitivity that I should try first before considering anything studied in a completed research trial like this one?
5Given that this trial focused on measuring dentinal hypersensitivity as its primary outcome, how would you personally assess whether a treatment is actually working for my sensitivity, and what improvement would be realistic to expect?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.