CompletedPhase 4

Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels

United States30 participantsStarted 2014-06

Plain-language summary

The investigators will study adaptation of motion perception and manual control in altered gravity, including the effects of a drug (promethazine). The investigators will also study whether promethazine affects motion perceptual thresholds.

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subjects must be in general good health Exclusion Criteria: * Anyone who is not generally in good general health does not qualify * Cardiovascular disease * Severe diabetes * Respiratory condition (e.g. asthma or emphysema) * Narrow angle glaucoma * Prostatic hypertrophy * Gastrointestinal disorders

What they're measuring

Percent Change in Roll Tilt Perception After Exposure to Hypogravity

Timeframe: 1 session

Yaw Perceptual Motion Threshold

Timeframe: 2 sessions separated by at least four days; measurements made 2 hrs after ingestion of medication

Roll Perceptual Motion Threshold

Timeframe: 2 sessions separated by at least four days; measurements made 2 hrs after ingestion of medication

Interaural Perceptual Motion Threshold

Timeframe: 2 sessions separated by at least four days; measurements made 2 hrs after ingestion of medication

Percent Change in Manual Control Performance After Exposure to Hypogravity

Timeframe: 1 session

Trial details

NCT IDNCT02136420

SponsorFaisal_Karmali@MEEI.HARVARD.EDU

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12

Results submitted2017-08-16

View on ClinicalTrials.gov More Vestibular trials