Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET)… (NCT02132052) | Clinical Trial Compass
CompletedNot Applicable
Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.
United States81 participantsStarted 2013-11
Plain-language summary
Investigators hypothesize that there are specific characteristic of each cognitive and motor condition that can be defined using brains scans.
Who can participate
Age range40 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* All subjects will be age 40 or older,
* Be on stable medications for at least 30 days
* Montreal Cognitive Assessment (MOCA) of 26 or higher
* Scores within 1.5 standard deviations of age-matched norms for all neuropsychological tests
* Parkinson's Plus Disorders (PD) will be defined using United Kingdom (UK) Brain Bank Criteria.
* PD dementia (PDD) will be defined using the Movement Disorder Task Force 2007 criteria and supported by scores less than 1.5 standard deviations of age-matched norms in at least two domains.
* Probable Alzheimer's Disease (AD) will be defined using the National Institute on Aging-Alzheimer Association 2011 guidelines.
* Parkinson's Plus Disorders (PD) with mild cognitive impairment (MCI) will be defined by history, MOCA of 21 or higher, at least one score less than 1.5 standard deviations of age-matched norms, and cannot meet diagnostic criteria for PDD.
* Essential tremor and Parkinson plus syndromes (multiple systems atrophy, corticobasal degeneration, progressive supranuclear palsy) will be defined using previously published research criteria.19-22
Exclusion Criteria
* Features suggestive of other causes of parkinsonism/Parkinson-plus syndromes;
* Features suggestive of other causes of dementia, including moderate to severe cerebrovascular disease by history, or imaging or history of major head trauma;
* History of deep brain stimulation, ablation surgery, or other brain surgery;
* Evidence for depression based on the Ho…