CompletedPhase 1

Regulation of Endogenous Glucose Production by Brain Insulin Action

Canada8 participantsStarted 2013-11

Plain-language summary

It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production. Animal studies have shown that the hormone insulin can act on the brain to indirectly lower glucose production by the liver. We aim to test whether this is true in humans by giving insulin intranasally. It has previously been shown that a nasal spray can deliver insulin directly to the brain without affecting circulating insulin concentration.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Men and women, aged 18 to 60 years
✓. Body mass index 20-27.
✓. Hemoglobin in the normal range.
✓. Normal glucose tolerance in response to a 75g, 2-hr oral glucose tolerance test
✓. Women of reproductive age should be on contraception (oral contraceptive pill or intra-uterine device/coil) for at least 2 months prior to and after the study.

What they're measuring

Endogenous glucose production

Timeframe: 8 hours

Trial details

NCT IDNCT02131948

SponsorUniversity Health Network, Toronto

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-07

View on ClinicalTrials.gov More Insulin Resistance, Diabetes trials