Background: \- An acquired heart disease is one that a person gets after they are born. Two of these are rheumatic heart disease (RHD) and endomyocardial fibrosis (EMF). They are found more commonly in people who live in Africa than in other places in the world. Researchers want to learn more about these diseases. They especially want to know what role genes and other factors play in them. Objective: \- To identify genetic risk factors for RHD and EMF in sub-Saharan Africa. Eligibility: * Children and adults with RHD or EMF. * Healthy volunteers over age 10. Design: * Participants will come from existing study groups in Uganda and Nigeria. * Participants may be required to provide a sample of their DNA. They will do this with either a blood or saliva sample or a swab of the mouth. * Collected samples will be labeled with a code and sent to a lab in the United States for analysis. Remaining portions of participants samples will be stored for an unlimited period of time. They may be used in future studies. * Some genetic and health information from participants might be placed into one or more scientific databases. * Participant names and identifying information will be kept private. But there is a small chance someone could trace them from their genetic information.
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Extension of study
Timeframe: ongoing