Active — Not RecruitingNot Applicable

Cognition in Older Breast Cancer Survivors: Treatment Exposure, APOE and Smoking History

United States499 participantsStarted 2014-04-08

Plain-language summary

In this study,the investigators are looking to see how older women who are survivors of breast cancer and either did or did not receive chemotherapy are affected by treatment, compared to older women who have never had cancer. Thinking and memory abilities normally decrease with age and the investigators want to see if the long-term effects of cancer treatments may make these problems worse. The investigators will also look at how thinking and memory abilities of older women are affected by genetics and smoking history. Genetics and other factors may affect the brain's chemicals or structure, and may either protect against the negative effects on thinking or make someone more at risk for them. MSK participants who previously consented to allostatic blood and saliva collection but have not yet provided any allostatic blood or saliva samples for this study, will not be asked to provide any further samples at follow-up. Participants who have consented to allostatic sample collection and provided one set of allostatic blood and saliva samples at a previous follow-up study visit will still be asked to provide a second set of samples at a later follow-up. COH participants will continue to provide allostatic blood and saliva collection as originally outlined

Who can participate

Age range60 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * The neuropsychological assessments were designed and validated in English and are not currently available in other languages. Translation of questionnaires into other languages would require reestablishing the reliability and validity of these measures. Therefore, participants must be able to communicate in English to complete the tests. Friend nominated, non-cancer controls will be frequency matched on age (+/- 5 years), education (less than college vs. some college and above), and race will be recruited using the same eligibility criteria as survivors except for no history of cancer. For cancer patients, eligibility includes: * As per medical record or self-report, post-menopausal female * As per medical record or self-report, age 60 or older at recruitment * As per medical record or self-report, age 55 or older at the time of breast cancer diagnosis * As per medical record or self report, for cancers other than breast cancer or non-melanoma/basal cell skin cancer/squamous cell skin cancer: * Patient must be at least 3 years post diagnosis of that cancer * Not received chemotherapy treatment or external beam radiation for that cancer * As per medical record or self-report, 5-15 years post diagnosis of breast cancer at the time of enrollment * As per medical record or self-report, no evidence of any cancer disease * American Joint Committee on Cancer (AJCC) stages 0-III breast cancer survivor as per clinical judgment/electronic medical record (E…

What they're measuring

neurocognitive outcomes

Timeframe: up to 24 months

Trial details

NCT IDNCT02122107

SponsorMemorial Sloan Kettering Cancer Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-04