CompletedNot Applicable

Blood Volume and Hemodynamic Analysis in Patients With Chronic Heart Failure

United States60 participantsStarted 2014-04-21

Plain-language summary

The primary hypothesis is that patients with HFREF (heart failure with reduced ejection fraction) will demonstrate a markedly expanded intravascular volume which will correlate with elevated right heart hemodynamics and increased venous capacitance parameters, whereas patients with HFPEF(heart failure with preserved ejection fraction) will demonstrate euvolemia to mild volume expansion and a lack of correlation with hemodynamic and venous compliance parameters.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \>18 years * patients identified with heart failure and diagnosed clinically to require right heart hemodynamic evaluation, New York Heart Association functional Class II-IV status/Stage C-D heart failure * ischemic or nonischemic etiology heart failure * left ventricular ejection fraction measured within 6 months of study enrollment Exclusion Criteria: * known significant intrinsic chronic kidney disease (baseline Glomerular Filtration Rate \<15 ml/min/1.73m²) or patients receiving hemodialysis * known renal artery stenotic disease * females who are pregnant * allergy to iodine contrast, intravenous pyelogram dye, shellfish or eggs.

What they're measuring

Total Blood Volume Measurement

Timeframe: Baseline prior to a clinically indicated right heart catheterization.

Trial details

NCT IDNCT02120014

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-07-06

View on ClinicalTrials.gov More Congestive Heart Failure trials