Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence

Inclusion Criteria: * Enrolled in methadone maintenance * Meets Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM V) criteria for active cocaine use * Submits one cocaine positive urine sample within 30 days of study start * Agrees to study procedures Exclusion Criteria: * Healthy and without contra-indications to study medication * Any history of epilepsy or seizure, including alcohol-, sedative-, or cocaine-related seizure * Any increased risk of seizure such as serious head trauma with a loss of consciousness of more than an hour duration, brain tumor, or other brain pathology increasing risk of seizure. * Current eating disorder including anorexia or bulimia * Current use (last 30 days) of antidepressants, antipsychotics, theophyllines, systemic steroids, monoamine oxidase (MAO-A) inhibitors. * Recent use (last 30 days) of budeprion, zyban®, wellbutrin®, aplenzin®, or any other medication containing bupropion. * Allergy to bupropion or budeprion * Liver enzymes greater than 3x ULN (upper limit of normal) * Uncontrolled diabetes mellitus, or h/o diabetic coma * Uncontrolled hypertension with BP \> 140/90. * Current psychiatric diagnosis: schizophrenia, psychosis, major depression, mania, current suicidal ideation as determined by MINI psychiatric interview, cognitive impairment severe enough to preclude informed consent or valid responses on questionnaires * Severe renal insufficiency (eGFR \< 30 ml/min) * Pregnancy or current breast feeding, * M…