Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Re… (NCT02107170) | Clinical Trial Compass
CompletedPhase 4
Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.
China68 participantsStarted 2014-02
Plain-language summary
Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.
Who can participate
Age range
18 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age 18-100 years of age
* Patients presenting for Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities
Exclusion Criteria:
* Patients with pre-existing delirium
* Inablility to converse
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compared different anesthetics to see which ones caused less postoperative cognitive dysfunction — do you know what those findings showed, and could they influence which anesthetic you'd recommend for my procedure?
2Since this was a Phase 4 study looking at real-world use of anesthetics in patients having endovascular aortic or lower extremity procedures, does the evidence from trials like this one change how you approach anesthesia choices for someone in my situation?
3Postoperative cognitive dysfunction can be a serious concern for patients undergoing vascular surgery — how will you monitor me for memory or thinking problems after my procedure, and what should I watch for at home?
4Given that I'd be having either an aortic aneurysm repair or a procedure for blocked leg arteries, are there specific anesthetic approaches that the current evidence suggests are safer for protecting brain function in patients with vascular disease like mine?
5Are there any factors in my personal health history — like my age, existing cognitive function, or other conditions — that would make the choice of anesthetic especially important to discuss before my surgery?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of patients with postoperative cognitive dysfunction