CompletedNot Applicable

Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia

Taiwan29 participantsStarted 2002-08

Plain-language summary

Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.

Who can participate

Age range

20 Years

Sex

ALL

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Inclusion Criteria: * Clinical diagnosis of Spinocerebellar ataxia * No history of epilepsy * No other neuromuscular disorder * No fracture within the last six months and restricted movement on the upper extremity * Limited trembling hand allowed for the EMG recording.

Questions worth asking your doctor

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1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

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Questions for the trial coordinator

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1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Central Motor Excitability

Timeframe: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.

Peripheral Motor Excitability

Timeframe: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.

Trial details

NCT IDNCT02103075

SponsorChang Gung University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2005-10

View on ClinicalTrials.gov More Spinocerebellar Ataxia trials