Negative Work Exercise for the Treatment of Knee Arthritis

Inclusion Criteria: * Adult men 50 y.o. 70 years old will be recruited for this proposed study. * Participant inclusion criteria includes having bilateral knee OA (Kellgren-Lawrence Grade 2 or 3) and sedentary (e.g., have not engaged in 3 exercise sessions per week for 3 consecutive months). * Gait aides and orthoses will not preclude participation in this study. Exclusion Criteria: * Exclusion criteria include uncontrolled cardiovascular disease, non-ambulatory status, neurogenic weakness, knee extensor and flexor manual muscle test \< 3 out of 5, lower extremity amputation, and current participation in a supervised exercise program. * In addition, major surgical procedures within the last six months, unstable joints, endocrine or metabolic disorders that result in excessive fatigue or muscle weakness, or use of medications that may impair exercise tolerance would also preclude participation in this study.