CompletedPhase 1/2

Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia

Norway8 participantsStarted 2014-03-27

Plain-language summary

The aim of this study is to compare the effects of tablet treatment, circadian and combined circadian and ultradian subcutaneous hydrocortisone infusion on steroid metabolism and tissue responses to therapy.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. clinical diagnosis of primary adrenal insufficiency
✓. Written informed consent

Exclusion criteria

✕. Diabetes mellitus
✕. Severe cardiovascular disease
✕. Active malignant disease
✕. Pregnancy or breast feeding
✕. treatment with interfering drugs
✕. Intake of grapefruit juice

What they're measuring

Serum cortisol -24 hours curve

Timeframe: 24 hours

Trial details

NCT IDNCT02096510

SponsorHaukeland University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12

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