Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Pati… (NCT02095275) | Clinical Trial Compass
UnknownNot Applicable
Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients
Taiwan300 participantsStarted 2012-01
Plain-language summary
B-type natriuretic peptide (BNP) is rapidly released by the ventricles of the heart in response to myocardial stretch. This cardiac neurohormone is mostly elevated in patients with fluid overload or myocardium dysfunction. BNP is a very useful and important marker. It can predict mortality and cardiac events in patients in the ICU setting. In stable hemodialysis patients with normal LV function on echocardiography, high BNP levels are likely the result of blood volume expansion and require reduction in postdialysis dry weight.
In the past, there were many methods to evaluate fluid status. Some are not reliable such as central venous pressure or physical examination. Some are invasive and expensive such as Swan Ganz、PiCCO catheter or bioimpedance device. Nevertheless, About the relationship between BNP and fluid status, a study found a significant relation between bioimpedance-derived body composition (BC) (fluid distribution) parameters and BNP concentrations. This relationship was independent of the cardiac history of the patient and suggests that the natriuretic peptide levels are to some degree modifiable by changing a patient's fluid distribution.
In this study, the investigators want to observe that if the level of BNP can predict the occurrence of acute kidney injury and the need of renal replacement therapy. Besides, the investigators also want to see if BNP can be a useful and convenient marker to guide adjustment of optimal fluid status and then to improve outcome.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients \> 18 y/o in ICU
Exclusion Criteria:
* Acute coronary syndrome
* Congestive heart failure history
* Clinical pulmonary hypertension with various cause (iPAH, congenital heart disease, CTEPH, COPD with cor pulmonate,…)
* Patients with acute pulmonary embolism
* Chronic atrial fibrillation,
* Respiratory failure with high PEEP (\>10 CmH2)
* Terminal cancer patients
* Patients with Bosmina therapy
* Patients received CPR (IHCA or OHCA)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is specifically looking at patients with nontraumatic acute kidney injury in the ICU — does my situation and type of kidney injury actually match what this study is enrolling?
2The trial is measuring BNP levels and fluid status alongside kidney function — can you explain what those measures mean for my care, and whether tracking them this way might give us useful information about my condition?
3Since the recruitment status is listed as 'unknown,' can you find out whether this study is still actively enrolling patients, or if it has already closed?
4The primary outcome is change in creatinine levels over 3 months — does that timeline align with where I am in my treatment, and is 3 months a realistic window for understanding my kidney recovery?
5Would participating in this observational-style study interfere with or delay any standard treatments I should be getting right now for my acute kidney injury?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline in serum creatinine level at 3 months