TerminatedNot Applicable

Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)

Stopped: Difficulties in reaching the desired number of patients and intermediate analysis leading to discontinuation of the study.

France21 participantsStarted 2014-09

Plain-language summary

The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus. So the corneal cross linking in association with the antibiotic treatment could result in a reduction of the duration of epithelial complete healing of the cornea.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infectious bacterial or fungal keratitis with : size \> 2mm or within the central corneal area ( 3mm of the visual axis ) or with a reaction in anterior chamber. * Being major responsible. * Agreement in writing to participate in the study. * Being affiliated to a national insurance scheme. Exclusion Criteria: * Present an infectious keratitis without all the previous criteria. * Herpes or acanthamoeba keratitis * preperforated or perforated cornea. General criteria: * Pregnant woman. * Minors(miners). * Adults under guardianship. * Patient can not be followed during 3 necessary months. * French speaking patient. * Unaffiliated patient in a national insurance scheme. * HIV infected patients

What they're measuring

Duration of corneal complete epithelial healing in days.

Timeframe: 3 months

Trial details

NCT IDNCT02088970

SponsorNantes University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-04

View on ClinicalTrials.gov More Bacterial Keratitis trials