PEG-ASP+Gemox Regimen and Thalidomide for NK/T Lymphoma

Inclusion criteria

• ✓. pathologically confirmed, previously untreated or refractory/relapsed ENKTL as defined by the World Health Organization classification;
• ✓. age≥18 years;
• ✓. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2;
• ✓. at least one measurable lesion;
• ✓. adequate haematologic function (haemoglobin \> 9.0 g/l, absolute neutrophil count \> 1500/ml, platelets \> 75,000/l),
• ✓. adequate hepatic function (total serum bilirubin ≤ 1.5 times the upper limit of normal, alanine aminotransferase and aspartate aminotransferase ≤ 2.5 times the upper limit of normal),
• ✓. adequate renal function (serum creatinine ≤ 1.5 mg/dl, creatinine clearance ≥ 50 ml/min);
• ✓. normal coagulation function and electrocardiogram results.