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Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation

France20 participantsStarted 2014-03

Plain-language summary

The occipital nerve stimulation (ONS) is used to treat patients with refractory primary chronic headache but its mechanism of action (MoA) remains unknown. Different hypothesis have been suggested in particular a specific action on cerebral generators involved in different types of primary headaches or a non specific action on pain modulatory network. The aim of this study, using the chronic cluster headache as a model, is to determine the changes in cerebral metabolism induced by ONS to precise its MoA in the treatment of primary chronic headache.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \> 18 years * chronic cluster headache (according to the IHS) * refractory in who a treatment by ONS have been indicated * patient affiliated at social security, * informed consent signed Exclusion Criteria: * contraindication to MRI * contraindication to 18F-FDG PET * women without contraception/pregnant/breast-feeding * patient non-compliant * patient on legal guardianship

What they're measuring

Comparison of cerebral metabolism

Timeframe: Baseline (before ONS), 1 week after ONS , 3 month after ONS

Trial details

NCT IDNCT02081482

SponsorCentre Hospitalier Universitaire de Nice

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

View on ClinicalTrials.gov More Refractory Chronic Cluster Headache trials