CompletedNot Applicable

Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CT

United States9 participantsStarted 2013-12

Plain-language summary

The purpose of this study is twofold: to assess routine cat scan (CT) imaging as a biomarker for removal of lipoprotein surfactant via lung lavage (where CT is the gold-standard imaging technique for density quantification), and to utilize a novel UTE MRI protocol to similarly quantify surfactant removal. This study will also serve to generate baseline scanning that may aid in developing analytical tools to evaluate and treat specific lung regions of patients with PAP.

Who can participate

Age range8 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Clinically diagnosed PAP scheduled for lung lavage with double lumen endoscopy. * Children patients ≥ 8 years of age * Adult patients ≤ 75 years of age * Medically stable as per the opinion of Bruce Trapnell, MD or Robert Wood, MD * Patient and or parent consent obtained Exclusion Criteria: * Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology * Pregnancy

What they're measuring

Comparing MRI's images pre and post whole lung lavage

Timeframe: 24 hours before lung lavage and 24-48 hours after lung lavage

Trial details

NCT IDNCT02081092

SponsorChildren's Hospital Medical Center, Cincinnati

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-10-29

View on ClinicalTrials.gov More Pulmonary Alveolar Proteinosis trials